Debunking the Synthetic Insulin Myth (Part I)

You would think someone with “MD” after her name would know better than to fall for quack medical articles.  Still, I could forgive Kelly Brogan, “Holistic Psychiatrist”, for her mistake in linking “Insulin Can Kill Diabetics; Natural Substances Heal Them”1 on her Facebook page,2 if only she had apologized for her mistake when it was pointed out to her.

Instead, Brogan plows mindlessly on, erasing critical posts, banning users who debunk her, and going on to spread more misinformation like, for example, the HIV virus not being responsible for AIDS,6 and claiming that we need viruses more than vaccines.2

FB thumbnail

Confirming a lie instead of debunking it–NOT what a doctor should be doing. See footnotes for image credit.

In a future article, I’ll debunk the myth that synthetic insulin is dangerous–and that pig-derived insulin is somehow safer.  In this article, however, I’d like to look at how people like Brogan and her source, “GreenMedInfo”, misrepresent real medical studies to scare the general public.  The study in question is called (hold on to your seats): “Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes: dose association with all-cause mortality, cardiovascular events, and incident cancer.”3

In this study, the researchers didn’t really look at when patients began insulin therapy and how the insulin affected the outcome.  Instead, they used a “proportional hazards model”, a statistical method in which they took a database of Type II diabetes patients from the United Kingdom, assumed synthetic insulin was a hazard, and introduced it mathematically over a designated period of time.

In other words, the researchers had no idea when the patients actually began insulin therapy and whether the insulin was a factor in the hazardous outcomes breathlessly reported by people misquoting and misrepresenting this study.  One thing that’s obviously missing is a control group–in this case, a group that did not receive the synthetic insulin.  The researchers do admit this, but everyone quoting the study ignores the fact.

So, all we really know from this study is that several years after 6,484 people with diabetes received synthetic insulin, some of them got sick, and some of those sick people eventually died.  Well, that’s exactly what you would expect in any population, especially if some of them are seriously ill.  The calculated adjusted hazard ratios in this study (e.g., 1.37 for major adverse/acute cardiovascular events, MACE) could just as easily be explained by pre-existing conditions or other factors.

In fact, a recent presentation at the 50th annual meeting of the European Association for the Study of Diabetes claimed that “pre-existing cardiovascular disease (CVD) emerged as the greatest risk factor for experiencing a major acute cardiovascular event (MACE) among patients with type 2 diabetes”.4  Wow.  Is it possible that patients with Type II diabetes are predisposed to cardiovascular disease?

Answer: Yes.  According to the American Heart Association, CVD is the cause of death in approximately 65% of all diabetes patients.5  All of a sudden, we’re running in circles: did the diabetes cause the CVD, or did the synthetic insulin?  Remember that missing control group?  What about the age of the patients?  What about when they actually began taking the insulin, as opposed the the arbitrary time selected by the researchers?  What about other health conditions?  What about…?

The researchers themselves were aware of the limitations of their study.  The last line of their abstract, missing from every quack article such as GreenMedInfo’s:

“Limitations of observational studies mean that this should be further investigated using an interventional study design”

An “interventional study” is what I hinted at earlier… it is a carefully controlled experiment involving, among other things, a control group that does not receive the drug (e.g., synthetic insulin) being tested.

There is nothing inherently wrong with an observational study, or statistical analysis.  The authors may very well have a point–maybe more studies are warranted.  I’ll leave that up to doctors.

What I want to point out is that one observational study does not–in any field, in any circumstances–prove a link between one thing and another.  And that is what’s being claimed by Dr. Brogan and everyone else citing this horrific GreenMedInfo article.

 

Image Credits
Dr. Brogan/Facebook screen snapshot used in accordance with Title 17 U.S.C. Section 107, commonly known as “fair use law”. This material is distributed without profit with the intent to provide commentary, review, education, parody, and increase public health knowledge.

 

References
Please note: To prevent increasing search engine exposure to quack web sites, I use the “DoNotLink” link obfuscator service to disguise URLs.  I promise that you are not being redirected to porn 🙂

(1)  (Quack Article) Research: Insulin Can Kill Diabetics; Natural Substances Heal Them
http://www.donotlink.com/crxt

(2) Dr. Brogan (Facebook)
http://www.donotlink.com/cryq

(3) Glucose-lowering with exogenous insulin monotherapy in type 2 diabetes (abstract)
http://onlinelibrary.wiley.com/doi/10.1111/dom.12412/abstract

(4) Pre-Existing Cardiovascular Disease Largest Risk Factor for MACE in Patients With Type 2 Diabetes
http://www.firstwordpharma.com/node/1236429#axzz3KxlconSQ

(5) AHA Scientific Statement: Diabetes and Cardiovascular Disease
http://circ.ahajournals.org/content/100/10/1134.full

(6) Kelly Brogan denies germ theory and the value of HIV drugs
http://sciblogs.co.nz/diplomaticimmunity/2014/09/23/kelly-brogan-denies-germ-theory-and-the-value-of-hiv-drugs/

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5 thoughts on “Debunking the Synthetic Insulin Myth (Part I)

  1. Quick note Mark. Dr. Brogan is a quack of the highest order. She even denies HIV is real (see the link below). She profits by scaring people into buy quackery that she sells.

    But those “inappropriate” responses are someone pretending to be her. They set up a fake account to look like her.

    http://sciblogs.co.nz/…/kelly-brogan-denies-germ…/

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      • If you want to take her unethical behavior to a different level, as of today she claims on her website to be a “NYU School of Medicine, NY Faculty, Clinical Instructor.” I have no doubt this was the case. However, if you look at this NYU Department of Psychiatry page, she is not a current faculty member. Maybe she just got lazy updating her webpage, but claiming credentials you do not have is a huge academic sin.
        http://psych.med.nyu.edu/faculty#B

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        • Oh dear… thank you for the tip! I’ve been amazed at the sh** she’s been dishing out in her career. In only recently discovered her. On one hand I hate to give her more publicity, but on the other, she is really dangerous. Having “MD” after your name and dishing out well-debunked woo… things that could get people killed… it’s just wrong.

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